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Studies suggest that exposure to endocrine-disrupting chemicals (EDCs) or alterations in the energy balance may also affect DNA methylation in the CL, potentially leading to luteal insufficiency ( Figure 7 ) ( Figure 7 3.2 Histone modifications in luteal cells Histone modifications including, acetylation and methylation, are important regulators of chromatin structure and gene accessibility in the progesterone-producing corpus luteum (CL)