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Once ubiquitinated, the ability of spectrin to bind to other components of the cytoskeletal complex is modified, and the ordered dissociation of key nodes such as spectrin–adducin–actin is promoted, thereby facilitating a dynamic network turnover [143]
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Spanning from meticulously isolated singular bioactive phytochemicals to synergistically formulated polyherbal compounds, Chinese medicinal preparations demonstrate extraordinary polypharmacological therapeutic capabilities characterized by multi-target engagement in CKD therapeutics (Ji et al., 2020
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