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Vehicle Compatibility:Super73 ZX SE / Z-Adv SE / Z Miami SE [Legacy Platform]
As a DAMP, cytosolic mtDNA is sensed by intracellular pattern recognition receptors (PRRs): TLR9 recognizes CpG-rich sequences and activates NF-κB and AP-1 via MyD88, cGAS binds mtDNA and synthesizes cGAMP to activate STING and trigger type I interferon responses, and AIM2 nucleates an inflammasome with ASC and Caspase-1 to drive IL-1β and IL-18 maturation (81–83)
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US$40
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