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Studies of decompensated cirrhosis and ACLF consistently show that patients with intense systemic inflammation can improve dramatically if the precipitating event is controlled but have high competing mortality risk ( The preferential response in ALD and in patients younger than 60 years with higher baseline MELD, preserved albumin (≥2.5 g/dL) and no HCC–defining the “ideal responder profile” – is biologically plausible

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Similarly, a decreased incidence was associated with the α 2C -AR Del322-325, whose receptor results in increase norepinephrine release (Chevalier et al., 2023)