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IGF-1 contains three disulphide bridges, between amino acids 6 and 48, 18 and 61 and 47 and 52, which create the tertiary structure critical for optimum binding to the IGF-1R (Figure 1)
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Further research found that RSL3 treatment induced ferroptosis in a manner that was similar to GPX4 inactivation, thus providing further evidence that RSL3 suppresses GPX4-induced ferroptosis (Yang et al., 2014)
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