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Although these peptide and protein aggregates likely increase local tissue stiffness at micron length-scales, they also promote chronic neuroinflammation, microglial reactivity/phagocytosis, and neurodegeneration which leads to the opposite mechanical effect at macro length-scales, i.e., a decrease in global tissue stiffness at millimeter length-scales (Hall et al., 2023
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The first report that a small peptide from human plasma could change how liver cells behaved in culture
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