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Protein Kinase C (PKC) pathway Under hyperglycemia, the intermediate glyceraldehyde-3-phosphate (G3P) produced by glycolysis can be converted into diacylglycerol (DAG), thereby activating the neuronal PKC pathway
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Targets of Novel AD Drugs The drugs currently approved or recommended for the treatment of AD belong to the category of agents targeting neurotransmitter receptors (cholinesterase inhibitors and N -methyl-d-aspartate receptor antagonists) and Aβ (monoclonal antibodies directed against Aβ plaques, protofibrils, and oligomers)
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