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That same review carries a caution worth stating alongside the benefit, which is that HA fractions at 20 kDa and below significantly increased expression of the pro-inflammatory cytokine TNF-alpha, leading Farwick and colleagues to conclude that fractions at or below 20 kDa are not recommended for application while 50 kDa was safe

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The RNA polymerase alternative σ factor RpoN/RpoS regulatory pathway, first described in a seminal report by Norgard and colleagues (8), controls gene expression via the effector alternative σ factor RpoS

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