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In vitro characterization of quercetin-loaded niosomes (Particle Size, Poly-dispersity Index, size distribution, and Zeta Potential Determination) Particle size and PDI are significant noisome characteristics that influence the particle’s dispersion, homogeneity, distribution, and subsequently targetability 34
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Possible reasons include the Washington State University patent holders not finding a pharmaceutical company willing to invest in development, the cancer biology concern with c-Met activation making development companies cautious, the preclinical effect sizes in rats not justifying the expense and risk of human trials, or other factors specific to drug development economics
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