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ROS are primarily produced in the cardiovascular and renal systems, whereas at the cellular level, they are formed by the mitochondria in the respiratory chain and by phagocytic cells through the enzyme nicotinamide adenine dinucleotide phosphate oxidase (NADPH oxidase, NOX), of which there are several isoforms
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Noise-induced cochlear synaptopathy in rhesus monkeys (Macaca mulatta)
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