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Potential side effects (usually related to the benzyl alcohol preservative) include: Allergic reactions (rare) Local irritation at injection site In neonates or very small infants, benzyl alcohol can cause toxicity (“gasping syndrome”) and should NOT be used

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GIP receptor activation (tirzepatide-specific): Enhanced insulin secretion in glucose-dependent fashion Improved fat metabolism in adipose tissue Possible nausea attenuation — tirzepatide trials have somewhat better GI tolerability than semaglutide trials at equivalent weight loss If REDEFINE 1's 6.6 percentage-point gain came from layering amylin on a GLP-1-only backbone, the same layering on a GLP-1 + GIP backbone could plausibly produce a larger gain — three non-overlapping pathways instead of two, with GIP's lipid-handling and possible GI-tolerability benefits adding to the case