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Through bioactivity-guided fractionation combined with HPLC-MS structural elucidation, we identified Bidentatide as the principal bioactive entity (Ding et al., 2021
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To comprehensively characterize the specificity of TP1 for HDAC4, we analyzed the effects of DMSO or TP1 via data-independent acquisition (DIA)-based quantitative proteomics after A549 cells were treated with TP1 or DMSO, and the results indicated that TP1 displays highly specific degradation activity towards HDAC4 (Fig
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