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Gene expression analyses showed that SLU-PP-332 upregulated PGC-1α, PGC-1β, and TFAM (transcription factor A mitochondrial), key regulators of mitochondrial biogenesis, along with expression of mitochondrial electron transport chain complex subunits and TCA cycle enzymes
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In human gene-expression datasets, GHK shifted the activity of genes involved in tissue remodelling, antioxidant defense and DNA repair towards a healthier pattern (Pickart et al., Oxid Med Cell Longev 2012)
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