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A number of animal groups, including primates, lack ascorbate biosynthesis capacity due to loss of function mutations in the biosynthetic enzyme L-gulono-1,4-lactone oxidase [1] but according to genome sequence analysis biosynthesis capacity may be lacking in other protist groups [2]

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Moreover, CBF reduction directly damages the cerebrovascular system, as evidenced by the widespread degeneration, detachment, and loss of pericytes, phenomena that are consistently observed in regions experiencing reduced CBF in various neurodegenerative diseases [94]