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This study describes a role for itaconate, production of which can be induced by type I interferons, in alkylating KEAP1 to increase the expression of antioxidant and anti-inflammatory genes upon lipopolysaccharide stimulation in macrophages
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As the degree of T-cell exhaustion increases, pathogens or tumor cells proliferate and spread, causing severe damage to the body (45) ( Figure 1 )
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