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Adenine model of chronic renal failure in rats to determine whether MCC950, an NLRP3 inflammasome inhibitor, is a renopreventive | BMC Nephrology | Springer Nature Link
In addition, studies have found that TMAO increases NADPH oxidase activity, induces the production of ROS, and an increase in ROS can promote the translocation of NF-κB from the cytoplasm to the nucleus (68)
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Nevertheless, to validate this hypothesis, it is essential to investigate the effects of these substances in an in vivo setting
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