glutathione adduct of diclofenac

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Bioactivation of Diclofenac via Benzoquinone Imine Intermediates—Identification of Urinary Mercapturic Acid Derivatives in Rats and Humans

Bioactivation of Diclofenac via Benzoquinone Imine Intermediates—Identification of Urinary Mercapturic Acid Derivatives in Rats and Humans

4.7 / 5 · 16 reviews

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Overview of bioactivation pathways considered to play a role in

Overview of bioactivation pathways considered to play a role in

4.0 / 5 · 20 reviews

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Fasting potentiates diclofenac-induced liver injury via inductions of oxidative/endoplasmic reticulum stresses and apoptosis, and inhibition of autophagy by depleting hepatic glutathione in mice

Fasting potentiates diclofenac-induced liver injury via inductions of oxidative/endoplasmic reticulum stresses and apoptosis, and inhibition of autophagy by depleting hepatic glutathione in mice

4.6 / 5 · 14 reviews

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Frontiers

Frontiers

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Full article: Bioactivation of diclofenac in human hepatocytes and the proposed human hepatic proteins modified by reactive metabolites

Full article: Bioactivation of diclofenac in human hepatocytes and the proposed human hepatic proteins modified by reactive metabolites

4.7 / 5 · 19 reviews

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The Key Role of GSH in Keeping the Redox Balance in Mammalian Cells: Mechanisms and Significance of GSH in Detoxification via Formation of Conjugates

The Key Role of GSH in Keeping the Redox Balance in Mammalian Cells: Mechanisms and Significance of GSH in Detoxification via Formation of Conjugates

4.5 / 5 · 25 reviews

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Full article: Diclofenac metabolism in the mouse: Novel in vivo metabolites identified by high performance liquid chromatography coupled to linear ion trap mass spectrometry

Full article: Diclofenac metabolism in the mouse: Novel in vivo metabolites identified by high performance liquid chromatography coupled to linear ion trap mass spectrometry

4.7 / 5 · 20 reviews

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Identification of quinone imine containing glutathione conjugates of diclofenac in rat bile

Identification of quinone imine containing glutathione conjugates of diclofenac in rat bile

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Figure 4 from Identification of quinone imine containing glutathione conjugates of diclofenac in rat bile

Figure 4 from Identification of quinone imine containing glutathione conjugates of diclofenac in rat bile

4.5 / 5 · 19 reviews

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LC-MS/MS detection of GSH adducts derived from diclofenac by constant

LC-MS/MS detection of GSH adducts derived from diclofenac by constant

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A) Diclofenac. (B) Proposed mechanisms of protein adduction at lysine

4.8 / 5 · 8 reviews

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IDENTIFICATION OF A NOVEL GLUTATHIONE ADDUCT OF DICLOFENAC, 4′-HYDROXY-2′-GLUTATHION-DESCHLORO-DICLOFENAC, UPON INCUBATION WITH HUMAN LIVER MICROSOMES

IDENTIFICATION OF A NOVEL GLUTATHIONE ADDUCT OF DICLOFENAC, 4′-HYDROXY-2′-GLUTATHION-DESCHLORO-DICLOFENAC, UPON INCUBATION WITH HUMAN LIVER MICROSOMES

4.7 / 5 · 28 reviews

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Diclofenac - an overview

Diclofenac - an overview

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Proposed scheme for the metabolic activation of diclofenac by acyl

4.4 / 5 · 8 reviews

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The pharmacokinetics and metabolism of diclofenac in chimeric humanized and murinized FRG mice | Archives of Toxicology

The pharmacokinetics and metabolism of diclofenac in chimeric humanized and murinized FRG mice | Archives of Toxicology

4.1 / 5 · 13 reviews

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Proposed metabolism of MRL-A to form M10 and the glutathione adduct,

Proposed metabolism of MRL-A to form M10 and the glutathione adduct,

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DETECTION OF A NOVEL REACTIVE METABOLITE OF DICLOFENAC: EVIDENCE FOR CYP2C9-MEDIATED BIOACTIVATION VIA ARENE OXIDES

DETECTION OF A NOVEL REACTIVE METABOLITE OF DICLOFENAC: EVIDENCE FOR CYP2C9-MEDIATED BIOACTIVATION VIA ARENE OXIDES

4.5 / 5 · 20 reviews

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STUDIES ON THE CHEMICAL REACTIVITY OF DICLOFENAC ACYL GLUCURONIDE WITH GLUTATHIONE: IDENTIFICATION OF DICLOFENAC-S-ACYL-GLUTATHIONE IN RAT BILE

STUDIES ON THE CHEMICAL REACTIVITY OF DICLOFENAC ACYL GLUCURONIDE WITH GLUTATHIONE: IDENTIFICATION OF DICLOFENAC-S-ACYL-GLUTATHIONE IN RAT BILE

4.0 / 5 · 19 reviews

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PDF] IDENTIFICATION OF A NOVEL GLUTATHIONE ADDUCT OF DICLOFENAC, 4′-HYDROXY-2′-GLUTATHION-DESCHLORO-DICLOFENAC, UPON INCUBATION WITH HUMAN LIVER MICROSOMES

PDF] IDENTIFICATION OF A NOVEL GLUTATHIONE ADDUCT OF DICLOFENAC, 4′-HYDROXY-2′-GLUTATHION-DESCHLORO-DICLOFENAC, UPON INCUBATION WITH HUMAN LIVER MICROSOMES

4.8 / 5 · 5 reviews

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Scheme 3. The GSH Conjugates of 4′-OH-Diclofenac, Which Can Be Formed

Scheme 3. The GSH Conjugates of 4′-OH-Diclofenac, Which Can Be Formed

4.8 / 5 · 24 reviews

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